Symptoms, Causes & Treatments of Sickle Cell Anemia
Sickle cell anemia is a genetic disorder that affects the hemoglobin, a protein in red blood cells responsible for carrying oxygen throughout the body. This disease causes the hemoglobin to form a sickle or crescent shape, leading to symptoms such as chronic pain, fatigue, and an increased risk of infections. The underlying cause of sickle cell anemia is a mutation in the HBB gene, which results in the production of abnormal hemoglobin. While there is no cure for sickle cell anemia, treatments such as Oxbryta and blood transfusions can help manage symptoms and improve quality of life. Here are the symptoms, causes, and treatments of sickle cell anemia: 1. Chronic pain One of the hallmark symptoms of sickle cell anemia is chronic pain. The sickled red blood cells block blood flow and oxygen supply to the affected tissues, leading to ischemia and tissue damage. The pain can occur in different parts of the body, including the chest, back, arms, legs, and abdomen. The pain can range from mild to severe and can be acute or chronic. Acute pain episodes can be triggered by various factors, such as stress, infection, dehydration, and exposure to extreme temperatures. Chronic pain can significantly affect the quality of life of people with sickle cell anemia, as it can interfere with their ability to work, socialize, and perform daily activities.